Richard C Boucher Selected Research

P-2165

1/2022

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.

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Richard C Boucher Research Topics

Disease

57	Cystic Fibrosis (Mucoviscidosis) 11/2022 - 02/2002
29	Inflammation (Inflammations) 11/2022 - 09/2002
28	Lung Diseases (Lung Disease) 12/2022 - 11/2003
17	Infections 11/2022 - 12/2004
13	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 04/2008
10	COVID-19 12/2022 - 01/2020
7	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2018 - 11/2008
6	Asthma (Bronchial Asthma) 01/2022 - 01/2005
6	Chronic Bronchitis 01/2017 - 07/2006
5	Bacterial Infections (Bacterial Infection) 01/2014 - 04/2003
4	Bronchiectasis 01/2022 - 12/2016
4	Ciliary Motility Disorders (Primary Ciliary Dyskinesia) 11/2018 - 05/2002
4	Dehydration (Water Stress) 02/2012 - 11/2004
4	Metaplasia 02/2012 - 04/2008
3	Chronic Disease (Chronic Diseases) 12/2022 - 12/2008
3	Airway Obstruction (Choking) 12/2018 - 05/2004
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2022 - 11/2020
2	Idiopathic Pulmonary Fibrosis 12/2020 - 01/2019
2	Hypoxia (Hypoxemia) 01/2019 - 02/2002
2	Pseudohypoaldosteronism 01/2018 - 01/2003
2	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2018 - 01/2014
2	Pneumonia (Pneumonitis) 02/2016 - 06/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 07/2006 - 05/2005
1	Tertiary Lymphoid Structures 02/2022
1	Rupture 01/2022
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 11/2021
1	Acute Lung Injury 11/2020
1	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 10/2019

Drug/Important Bio-Agent (IBA)

24	MucinsIBA 12/2022 - 11/2004
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
13	Adenosine Triphosphate (ATP)IBA 01/2022 - 05/2003
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2009
11	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 04/2003
10	CytokinesIBA 12/2022 - 09/2002
7	Amiloride (Midamor)FDA LinkGeneric 12/2008 - 01/2003
6	Epithelial Sodium ChannelsIBA 01/2018 - 12/2004
5	NucleotidesIBA 01/2017 - 08/2003
5	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 04/2013 - 01/2004
5	Chloride Channels (Chloride Channel)IBA 01/2011 - 09/2002
4	RNA (Ribonucleic Acid)IBA 12/2022 - 01/2020
4	Angiotensin-Converting Enzyme 2IBA 01/2022 - 01/2020
4	Urea (Carbamide)FDA LinkGeneric 01/2017 - 06/2009
4	SodiumIBA 01/2016 - 06/2007
4	Anti-Bacterial Agents (Antibiotics)IBA 05/2012 - 02/2006
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2009 - 09/2002
3	Antiviral Agents (Antivirals)IBA 02/2022 - 05/2021
3	Interleukin-13IBA 01/2022 - 04/2008
3	Messenger RNA (mRNA)IBA 12/2020 - 10/2012
3	Mucin-5BIBA 01/2019 - 11/2018
3	SmokeIBA 11/2018 - 02/2012
3	PurinesIBA 12/2016 - 06/2009
3	Pharmaceutical PreparationsIBA 06/2014 - 01/2014
3	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 04/2013 - 01/2006
3	Phenobarbital (Luminal)FDA Link 10/2012 - 03/2005
3	Adenosine Monophosphate (AMP)IBA 10/2011 - 08/2004
2	Expectorants (Mucolytics)IBA 12/2022 - 01/2019
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2022 - 01/2019
2	LigandsIBA 12/2022 - 01/2005
2	Interleukin-6 (Interleukin 6)IBA 03/2022 - 07/2003
2	Mucin 5ACIBA 01/2022 - 01/2019
2	GoldIBA 01/2022 - 10/2011
2	AerosolsIBA 01/2022 - 07/2006
2	Detergents (Detergent)IBA 01/2022 - 05/2021
2	Glycoproteins (Glycoprotein)IBA 01/2022 - 01/2022
2	Surface-Active Agents (Surfactants)IBA 12/2020 - 11/2020
2	Transcription Factors (Transcription Factor)IBA 12/2020 - 01/2018
2	Ion Channels (Ion Channel)IBA 01/2018 - 01/2013
2	EnzymesIBA 12/2016 - 12/2015
2	purineIBA 08/2015 - 06/2009
2	Phenylalanine (L-Phenylalanine)FDA Link 04/2013 - 10/2011
2	Sodium Channels (Sodium Channel)IBA 04/2012 - 11/2007
2	Cyclic AMP (AMP, Cyclic)IBA 06/2009 - 08/2004
2	ChitinasesIBA 04/2009 - 04/2008
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2005 - 08/2004
1	Periodic AcidIBA 12/2022
1	Alcian BlueIBA 12/2022
1	ErbB Receptors (EGF Receptor)IBA 12/2022
1	DNA (Deoxyribonucleic Acid)IBA 11/2022
1	Peptide Hydrolases (Proteases)FDA Link 03/2022
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 03/2022
1	tocilizumab (atlizumab)FDA Link 03/2022
1	molnupiravirIBA 02/2022
1	nintedanibIBA 02/2022
1	CollagenIBA 02/2022
1	P-2165IBA 01/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	Methionine (L-Methionine)FDA Link 01/2022
1	Proline (L-Proline)FDA Link 01/2022
1	Sulfhydryl Compounds (Thiols)IBA 01/2022
1	Reducing AgentsIBA 01/2022
1	(2R,3R,4R,5S)- 6- (((2S,3R,4R,5R)- 2,3,4,5,6- pentahydroxyhexyl)- (2- (4- (sulfanylmethyl)phenoxy)ethyl)amino)hexane- 1,2,3,4,5- pentolIBA 01/2022
1	IsotopesIBA 11/2021
1	LaxativesIBA 11/2021
1	InterferonsIBA 12/2020
1	LuciferasesIBA 01/2020
1	Erythromycin (Erycette)FDA LinkGeneric 01/2020

Therapy/Procedure

31	Therapeutics 01/2022 - 11/2003
2	Drug Therapy (Chemotherapy) 01/2020 - 06/2008
2	Fluid Therapy (Oral Rehydration Therapy) 09/2013 - 01/2007
1	Precision Medicine 01/2021